Queensland Centre for Gynaecological Cancer Research

ENDO-3 Trial

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The #ENDO3trial is a big step towards generating evidence in surgical treatment of endometrial cancer.

It is a randomised controlled trial that compares Sentinel Lymph Node Dissection (SLND), a commonly performed procedure for the surgical staging of endometrial cancer, to No Node Dissection.

The outcomes from this world-first trial will provide high-level evidence on sentinel lymph node dissection’s effectiveness, benefit and harm to patients and will determine the value of retaining or discontinuing this procedure in the treatment of apparent early stage endometrial cancer.

The ENDO-3 trial opened for recruitment in January 2021 at the Royal Brisbane & Women's Hospital and The Wesley Hospital. The first patient was enrolled in February 2021 and the aim is to recruit 760 patients. Currently we have 8 Australian sites collaborating on the ENDO-3 Trial with more in the pipeline, including international sites.

221 patients have been enrolled to date from 10 national and international sites:

  • Buderim Private Hospital, QLD
  • Chris O'Brien Lifehouse, NSW
  • Mater Hospital, QLD
  • North West Private Hospital, QLD
  • Royal Brisbane & Women's Hospital, QLD
  • St Andrews War Memorial Hospital, QLD
  • The Royal Womens Hospital, VIC
  • The Wesley Hospital, QLD
  • Houston Methodist, USA
  • Singapore National University Hospital, Singapore

27 surgeons, both nationally and internationally, have successfully passed accreditation in Sentinel Node Biopsy (SNB) as part of the ENDO-3 Trial, with more surgeons currently undergoing the process!

  • Dr Guilherme Accorsi, Dr Michael Burling, Dr Nimithri Cabraal, Dr Naven Chetty, A/Prof Rhonda Farrell, Dr Andrea Garrett, Dr Nisha Jagasia, Dr Nicole Krzys, A/Prof Russell Land, Dr Jagannath Mishra, Dr Shaun McGrath, A/Prof Orla McNally, Dr Rhett Morton, Dr Deborah Neesham, Dr Joseph Ng, Prof James Nicklin, Prof Andreas Obermair, Dr Adam Pendlebury, Prof Pedro Ramirez, Dr Stefano Restaino, Dr Piksi Singh, Dr Pearl Tong, Dr David Viveros, A/Prof Giuseppe Vizzielli, Dr Tarrik Zaid & A/Prof Behrouz Zand.

 

Masterclass: SNB in Endometrial Cancer - 18 July 2022

Recently we ran a Masterclass in SNB for Endometrial Cancer.  To watch this recording, register here and use passcode g+rfG%3E to view.