ENDO-3 is a proposed randomised controlled trial (RCT) that will compare sentinel lymph node dissection (SLND), a commonly performed procedure for the surgical staging of endometrial cancer (EC), to no node dissection. The outcomes from our RCT will provide high-level evidence on SLND’s effectiveness, benefit and harm to patients and will determine the value of retaining or discontinuing this procedure in the treatment of apparent early stage EC.